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Cat No: 13258
Biochemicals - Receptor Pharmacology

There are two homologous nuclear receptors for the hormone 17β-estradiol (estrogen), commonly called ERα and ERβ. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene tra...


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Territorial Availability: Available through Bertin Technologies only in France
  • 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine
Correlated keywords:
  • nuclear receptors 17?-estradiol estrogen ER? ER? modulators antagonists breast cancers tumors agonists bones osteoporosis cardiovascular disease menopause women uterus uterine endometrial carcinomas Nolvadex Istubal Valodex Savient brand of Tamoxifen Citrate Citrate Tamoxifen Tamoxifen Citrate Zitazonium Tomaxithen ICI-4 474 ICI 46 474Tamoxifen ICI-47699 ICI-46474 ICI46474ICI 47699 ICI 46474 Soltamox Novaldex Nolvadex ICI47699 ICI46474
Product Overview:
There are two homologous nuclear receptors for the hormone 17β-estradiol (estrogen), commonly called ERα and ERβ. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is a selective estrogen receptor modulator, evoking tissue-dependent effects. It is an antagonist of ER action in breast tissue and breast cancer cells and is reported to be effective in the treatment of early breast cancer to prevent tumor growth.{17813,17814} Importantly, tamoxifen has been reported to act as an ER agonist in bone and blood vessels, helping to minimize osteoporosis and reduce the risk of cardiovascular disease in post-menopausal women.{17815} Also, tamoxifen is a partial ER agonist in uterine tissues and is reported to increase the risk of endometrial carcinoma.{17816}
Size 500 mg
Shipping dry ice
CAS Number 10540-29-1
Molecular Formula C26H29NO
Molecular Weight 371,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2921.44
UNSPSC code 12352100

Hall, J.M., Couse, J.F., and Korach, K.S. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276(40) 36869-26872 (2001).

Zhu, Y., Qi, C., Jain, S., et al. Amplification and overexpression of peroxisome proliferator-

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