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Tamoxifen

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    Tamoxifen
  • Tamoxifen
Cat No: 13258
Biochemicals - Receptor Pharmacology
Cayman
€59.00
Price is excluding VAT and does not include packaging neither shipping

There are two homologous nuclear receptors for the hormone 17β-estradiol (estrogen), commonly called ERα and ERβ. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene tra...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine
Correlated keywords:
  • nuclear receptors 17β-estradiol estrogen ERα ERβ modulators antagonists breast cancers tumors agonists bones osteoporosis cardiovascular disease menopause women uterus uterine endometrial carcinomas Nolvadex Istubal Valodex Savient brand of Tamoxifen Citrate Citrate Tamoxifen Tamoxifen Citrate Zitazonium Tomaxithen ICI-4 474 ICI 46 474Tamoxifen ICI-47699 ICI-46474 ICI46474ICI 47699 ICI 46474 Soltamox Novaldex Nolvadex ICI47699 ICI46474
Product Overview:
There are two homologous nuclear receptors for the hormone 17β-estradiol (estrogen), commonly called ERα and ERβ. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is a selective estrogen receptor modulator, evoking tissue-dependent effects. It is an antagonist of ER action in breast tissue and breast cancer cells and is reported to be effective in the treatment of early breast cancer to prevent tumor growth.{17813,17814} Importantly, tamoxifen has been reported to act as an ER agonist in bone and blood vessels, helping to minimize osteoporosis and reduce the risk of cardiovascular disease in post-menopausal women.{17815} Also, tamoxifen is a partial ER agonist in uterine tissues and is reported to increase the risk of endometrial carcinoma.{17816}
Size 500 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 10540-29-1
Molecular Formula C26H29NO
SMILES CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3
Molecular Weight 371,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2921.44
UNSPSC code 12352100

Hall, J.M., Couse, J.F., and Korach, K.S. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276(40) 36869-26872 (2001).

Zhu, Y., Qi, C., Jain, S., et al. Amplification and overexpression of peroxisome proliferator-

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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