Prostaglandin E1 ethyl ester

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Prostaglandin E₁ ethyl ester

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Cat No: 9001730

Biochemicals - Lipids

Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human pla...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

11?,15S-dihydroxy-9-oxo-prost-13E-en-1-oic acid, ethyl ester

Correlated keywords:

prostaglandins atherosclerosis hypertension cardiology esterified esters ethyl PGs PGEs E1 cyclooxygenase COXs metabolite dihomo-g-linolenic dihomo-gamma-linolenic dihomo-.gamma.-linolenic dihomo-?-linolenic ADP-induced ADPs induced platelet aggregation male erectile dysfunction ductus arteriosus patency infants babies baby applications reproductive biology

Product Overview:
Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} PGE1 is used to treat male erectile dysfunction and to maintain ductus arteriosus patency in infants.{3468,5876} PGE1 ethyl ester is an esterified form of the free acid which may be more amenable for certain applications.

Size	100 µg
Shipping	dry ice
CAS Number	35900-16-4
Molecular Formula	C₂₂H₃₈O₅
SMILES	O=C1[C@H](CCCCCCC(OCC)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
Molecular Weight	382,5
Formulation	A solution in methyl acetate
Purity	≥95%
Custom Code	2932.99
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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