PSMA (C-Term) Rabbit Monoclonal

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PSMA (C-Term) Rabbit Monoclonal Antibody

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Cat No: 32265

Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein and a glutamate-preferring carboxypeptidase with roles in folic acid utilization and metabolism encoded by FOLH1 in humans.{60113,60116} It is composed of a short intracellul...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

RM-327 GCP-II FOLH-1 NAALAD Carboxy-peptidase glyco-protein

Product Overview:
Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein and a glutamate-preferring carboxypeptidase with roles in folic acid utilization and metabolism encoded by FOLH1 in humans.{60113,60116} It is composed of a short intracellular domain, a transmembrane domain, and a large extracellular region that contains enzymatic domains.{60113,60114} PSMA is expressed in prostate epithelial cells and is highly overexpressed in prostate carcinomas. PSMA is also expressed in the central nervous system, where it metabolizes N-acetyl-aspartyl-glutamate, and in the proximal small intestine, where it functions as a carboxypeptidase and a folate hydrolase, as well as in the neovasculature of various renal, colon, and breast carcinomas.{60116,60115} Expression of FOLH1 increases under androgen deprivation conditions in vitro and in vivo and positively correlates with cancer aggressiveness in patients with prostate cancer.{60113} PSMA positron emission tomography (PET) imaging is commonly used in the diagnosis and staging of prostate cancer, as well as to assess therapeutic response.{60114} Cayman’s PSMA (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	A peptide from the C-terminal region of human PSMA
Clone	RM327
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.