ITGAM/CD11b (C-Term) Rabbit Mono

Confirm delete?

ITGAM/CD11b (C-Term) Rabbit Monoclonal Antibody

Zoom

Cat No: 32241

CD11b, also known as integrin αM (ITGAM), is a protein subunit of the heterodimeric leukocyte integrin αMβ2, the major integrin expressed in phagocytes with roles in host defense.{59670} It is composed of an ectodomain containing a β-propeller domain ...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

immuno chemical trans membrane histochemistry histo chemistry MAC1

Product Overview:
CD11b, also known as integrin αM (ITGAM), is a protein subunit of the heterodimeric leukocyte integrin αMβ2, the major integrin expressed in phagocytes with roles in host defense.{59670} It is composed of an ectodomain containing a β-propeller domain followed by a thigh domain and calf-1 and calf-2 domains, a transmembrane segment, and a cytoplasmic tail.{59670,59671} CD11b is expressed as a component of αMβ2 on the surface of leukocytes, including macrophages, dendritic cells, monocytes, neutrophils, natural killer cells, and granulocytes, that binds to ICAM and VCAM to facilitate macrophage extravasation, as well as complement C3-opsonized pathogens and immune complexes to mediate their internalization and phagocytosis.{59670} Mutations in ITGAM are associated with susceptibility to systemic lupus erythematosus (SLE).{59672} Cayman’s ITGAM/CD11b (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human CD11b
Clone	RM290
Isotype	IgG
Application(s)	IHC and WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.