SCF Extracellular Domain (human,

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SCF Extracellular Domain (human, recombinant)

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Cat No: 32051

Proteins - More Proteins

Stem cell factor (SCF), also known as steel factor or c-Kit ligand, is a growth factor and cytokine that promotes proliferation, migration, survival, and differentiation of hematopoietic progenitors, germ cells, and melanocytes and is encoded by KITLG...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

cKit melano cytes extra intra cellular homo dimerize CD 34 Glu 26 SHEP 7 DCUA FPH 2 FPHH Kitl KL 1 SCF SF

Product Overview:
Stem cell factor (SCF), also known as steel factor or c-Kit ligand, is a growth factor and cytokine that promotes proliferation, migration, survival, and differentiation of hematopoietic progenitors, germ cells, and melanocytes and is encoded by KITLG in humans.{54153} It is composed of an extracellular domain that contains a c-Kit binding region, a transmembrane domain, and a C-terminal intracellular tail and is ubiquitously expressed by fibroblasts and endothelial cells. SCF also exists as a soluble form produced by proteolytic cleavage of a membrane-bound isoform of SCF produced by alternative splicing and lacking exon 6. Both membrane-bound and soluble SCF homodimerize and bind to the SCF receptor, also known as c-Kit, to induce intracellular signaling. Allergen exposure increases lung and serum levels of SCF in a mouse model of allergic inflammation, and airway levels of SCF are increased in patients with asthma.{54152} Exogenous administration of SGF decreases infarct size and improves motor function in a spontaneously hypertensive rat model of stroke induced by middle cerebral artery occlusion.{54154} SCF inhibits apoptosis of CD34+ acute myeloid leukemia cells induced by cytarabine (Item No. 16069), daunorubicin (Item No. 14159), or carboplatin (Item No. 13112).{54155} Cayman's SCF Extracellular Domain (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 175 amino acids, has a calculated molecular weight of 19.9 kDa, and a predicted N-terminus of Glu26 after signal peptide cleavage.

Size	100 µg
Shipping	dry ice
Formulation	Lyophilized from sterile 20 mM Tris, 500 mM sodium chloride, pH 8.0
Purity	≥92% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.