Terbutaline

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Terbutaline

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Cat No: 29337

Biochemicals - Receptor Pharmacology

Terbutaline is a short-acting β2-adrenergic receptor (β2-AR) agonist and an active metabolite of bambuterol (Item No. 17887).{25395,45643,45644} It binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases ad...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol

Correlated keywords:

46719-29-3 ± Aerodur AR-D 080301 ARD ARD080301 DO80301 Dihydroxyphenyl butylamino tert ethanol Brican Bricar Bricaril Bricyn Fasma KWD 2019 KWD2019 Terbutalin ?2AR ?-2 1 ?3AR 3 D-4 LTD

Product Overview:
Terbutaline is a short-acting β2-adrenergic receptor (β2-AR) agonist and an active metabolite of bambuterol (Item No. 17887).{25395,45643,45644} It binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values.{25395} Terbutaline inhibits histamine release induced by ovalbumin in isolated guinea pig lung mast cells.{45643} It also inhibits airway obstruction induced by methacholine (acetyl-β-methylcholine; Item No. 23092) or leukotriene D4 (LTD4; Item No. 20310) in anesthetized guinea pigs.{45645} Formulations containing terbutaline have been used in the treatment of asthma.

Size	25 mg
Shipping	dry ice
CAS Number	23031-25-6
Molecular Formula	C₁₂H₁₉NO₃
SMILES	OC1=CC(O)=CC(C(O)CNC(C)(C)C)=C1
Molecular Weight	225,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.50
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.