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Melanocortin-4 Receptor Polyclonal Antibody

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    Melanocortin-<wbr/>4 Receptor Polyclonal Antibody
  • Melanocortin-<wbr/>4 Receptor Polyclonal Antibody
Cat No: 10006355

Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'.{12351} These actions are mediated (differentia...

: 1 ea

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • antibodies antisera antiserum WB western blots blotting IHC immunohistochemistry melanocortins melanogenesis steroidogenesis sexual functions inflammations appetite regulations energy homeostasis G-proteins coupled receptors GPCRs MC1R MC2R MC3R MC5R transcripts brain genetic studies heteozygous mutations human obesity mammalian unglycosylated SDS-PAGE endocrinology immunoblotting
Product Overview:
Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'.{12351} These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors, the melanocortin receptors 1-5 (MC1R-MC5R). Melanocortin-4 receptor (MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain.{13229} Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation.{3777} Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity.{10617} All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE.{13230} Cayman’s MC4R Polyclonal Antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.
Size 1 ea
Shipping dry ice
Host Rabbit
Antigen Synthetic peptide from the N-terminal region of mouse protein MC4R

IHC (formalin-fixed paraffin-embedded sections) and WB

Formulation 500 µl of Peptide affinity-purified antibody
Custom Code 3822.19
UNSPSC code 12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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