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Cat No: 15025
Biochemicals - Small Molecule Inhibitors

Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Item No. 70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond.{22572} This bond is rapidly cleaved by bacteria in the terminal ileum and c...


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Territorial Availability: Available through Bertin Technologies only in France
  • 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-benzoic acid
Correlated keywords:
  • anti-inflammatory 5-aminosalicylic acid 5-ASA inflammatory bowel diseases rheumatoid arthritis NF?B cytokines PPAR? anti antiinflammatory inflammatory 5ASA ASA 5 PPAR-? PPARs PPAR-gamma PPARgamma gamma PPAR-.gamma. PPAR.gamma. .gamma. PPARg PPAR-g g antibiotics sulfapyridine azo bonds pro-drugs prodrugs pro drugs COX cyclooxygenase 5-LO lipoxygenases pathways azopyrine azulfidine azulfidine EN azulfidine-EN azulfin benzosulfa colo-pleon colopleon colo pleon NSC203730 NSC-203730 NSC 203730 NSC667219 NSC-667219 NSC 667219 reuprin salazopyridine salazopyrin salazopyrine salazosulfapyridin salazosulfapyridine salicylazosulfapuridine salisulf sulfasalazine sulfasalazine sulphasalazine agents bacteria terminal ileum colons IBD RA T lymphocytes apoptosis cells deaths modulates modulations mediators COX/5-LO cyclooxygenase/5-lipoxygenase attenuates transcriptions factors proinflammatory cytokines NF-?B NF-kB NF-kappaB NF-.kappa.B nuclear ferroptosis
Product Overview:
Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Item No. 70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond.{22572} This bond is rapidly cleaved by bacteria in the terminal ileum and colon, releasing the active anti-inflammatory component. Sulfasalazine (0.1-5 mM) inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells.{9108} It also inhibits degradation of IκBα and prevents nuclear translocation of NF-κB induced by TNF-α. Sulfasalazine (0.25 mM) inhibits cystine uptake through the system xc- cysteine-glutamate transporter and inhibits the growth of U-87MG glioma cells in an NF-κB independent manner when used at concentrations ranging from 0.25 to 1 mM.{48002} Sulfasalazine (100 mg/kg) decreases diarrhea, increases food intake, and reverses body weight decreases in a mouse model of colitis.{22572} It is also suppresses antigen-induced arthritis in mice.{48003} Formulations containing sulfasalazine have been used in the treatment of ulcerative colitis and rheumatoid arthritis.
Size 5 g
Shipping dry ice
CAS Number 599-79-1
Molecular Formula C18H14N4O5S
SMILES OC(C(C(O)=O)=C1)=CC=C1/N=N/C2=CC=C(S(NC3=CC=CC=N3)(=O)=O)C=C2
Molecular Weight 398,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2930.90
UNSPSC code 12352100

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