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Sulfasalazine

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    Sulfasalazine
  • Sulfasalazine
Cat No: 15025
Biochemicals - Small Molecule Inhibitors
Cayman
€46.00
Price is excluding VAT and does not include packaging neither shipping

Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Item No. 70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond.{22572} This bond is rapidly cleaved by bacteria in the terminal ileum and c...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-benzoic acid
Correlated keywords:
  • anti-inflammatory 5-aminosalicylic acid 5-ASA inflammatory bowel diseases rheumatoid arthritis NFκB cytokines PPARγ anti antiinflammatory inflammatory 5ASA ASA 5 PPAR-γ PPARs PPAR-gamma PPARgamma gamma PPAR-.gamma. PPAR.gamma. .gamma. PPARg PPAR-g g antibiotics sulfapyridine azo bonds pro-drugs prodrugs pro drugs COX cyclooxygenase 5-LO lipoxygenases pathways azopyrine azulfidine azulfidine EN azulfidine-EN azulfin benzosulfa colo-pleon colopleon colo pleon NSC203730 NSC-203730 NSC 203730 NSC667219 NSC-667219 NSC 667219 reuprin salazopyridine salazopyrin salazopyrine salazosulfapyridin salazosulfapyridine salicylazosulfapuridine salisulf sulfasalazine sulfasalazine sulphasalazine agents bacteria terminal ileum colons IBD RA T lymphocytes apoptosis cells deaths modulates modulations mediators COX/5-LO cyclooxygenase/5-lipoxygenase attenuates transcriptions factors proinflammatory cytokines NF-κB NF-kB NF-kappaB NF-.kappa.B nuclear ferroptosis
Product Overview:
Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Item No. 70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond.{22572} This bond is rapidly cleaved by bacteria in the terminal ileum and colon, releasing the active anti-inflammatory component. Sulfasalazine (0.1-5 mM) inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells.{9108} It also inhibits degradation of IκBα and prevents nuclear translocation of NF-κB induced by TNF-α. Sulfasalazine (0.25 mM) inhibits cystine uptake through the system xc- cysteine-glutamate transporter and inhibits the growth of U-87MG glioma cells in an NF-κB independent manner when used at concentrations ranging from 0.25 to 1 mM.{48002} Sulfasalazine (100 mg/kg) decreases diarrhea, increases food intake, and reverses body weight decreases in a mouse model of colitis.{22572} It is also suppresses antigen-induced arthritis in mice.{48003} Formulations containing sulfasalazine have been used in the treatment of ulcerative colitis and rheumatoid arthritis.
Size 5 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 599-79-1
Molecular Formula C18H14N4O5S
SMILES OC(C(C(O)=O)=C1)=CC=C1/N=N/C2=CC=C(S(NC3=CC=CC=N3)(=O)=O)C=C2
Molecular Weight 398,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2930.90
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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