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Olsalazine (sodium salt)

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    Olsalazine (sodium salt)
  • Olsalazine (sodium salt)
Cat No: 23661
Biochemicals - Small Molecule Inhibitors
Cayman

Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA; Item No. 70265) that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.{30379} In vitro, olsalazine increases ion t...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3,3'-(1,2-diazenediyl)bis[6-hydroxy-benzoic acid, disodium salt
Correlated keywords:
  • 15722-48-2 5ASA CI14130 chrome flavine R alizarol A azodisal chromaven yellow FA fast J extra AS 3R diamond ex dipentum azodisalicylate eriochromal eriochrome fenakrom 3G metachrome mordant monochrome nutrachrome NYA olsalazine omega aurine GL Ph CJ 91B pontachrome salicine synchromate telon tertrochrome
Product Overview:
Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA; Item No. 70265) that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.{30379} In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of 5 mM.{41622,41623} Olsalazine (150 mg/kg for 8 days) improves stool consistency and decreases occult and gross bleeding as well as myeloperoxidase (MPO) activity and leukotriene B4 (LTB4; Item No. 20110) levels in colon tissue in a mouse model of acute colitis induced by dextran sulfate (Item No. 23250).{41624} Olsalazine also inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L) and lowers serum uric acid levels in a mouse model of hyperuricemia induced by oxonic acid (Item No. 22586) when administered at a dose of 20 mg/kg.{41625} Formulations containing olsalazine have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.
Size 250 mg
Shipping dry ice
CAS Number 6054-98-4
Molecular Formula C14H8N2O6 • 2Na
SMILES [O-]C(C1=C(O)C=CC(/N=N/C2=CC=C(O)C(C([O-])=O)=C2)=C1)=O.[Na+].[Na+]
Molecular Weight 346,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2916.39
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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