Piperonyl Butoxide

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Piperonyl Butoxide

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Cat No: 25820

Biochemicals - Small Molecule Inhibitors

Piperonyl butoxide is a synergist used to enhance the activity of insecticides, including pyrethrin insecticides, through inhibition of cytochrome P450 enzymes (CYPs).{37755,37756} It increases the toxicity of the pyrethroid insecticide deltamethrin (...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Correlated keywords:

12750-92-4 Butacide Buticide Butocide ENT 14,250 ENT14,250 ENT14250 Incite NSC8401 PBO Piperonylbutoxide Zengxiaomi CYP450 Cimex Spodoptera Hyalella chironomus Lytechinus

Product Overview:
Piperonyl butoxide is a synergist used to enhance the activity of insecticides, including pyrethrin insecticides, through inhibition of cytochrome P450 enzymes (CYPs).{37755,37756} It increases the toxicity of the pyrethroid insecticide deltamethrin (Item No. 24172) to field-collected, deltamethrin-resistant strains of the bed bug C. lectularius by 40- to 176-fold when used at a concentration of 50 μg/μL.{37756} Piperonyl butoxide also increases the toxicity of the organotin insecticide Plictran to fourth instar larvae of susceptible strains of the cotton leafworm S. littoralis (LD50s = 0.78 and 40 μg/larva with and without piperonyl butoxide, respectively), as well as field strains (LD50s = 0.015 and 1.1 μg/larva with and without piperonyl butoxide, respectively).{43336} It is not toxic to the freshwater invertebrates H. azteca, C. tentans, and L. variegatus (LC50s = 530, 2,740, and 3,540 μg/L, respectively) and reduces the toxicity of the organophosphate pesticides diazinon (Item No. 23769), chlorpyrifos (Item No. 21412), and azinphos-methyl, which require activation by CYP enzymes in these organisms.{37755} Formulations containing piperonyl butoxide have been used for the control of agricultural, household, and veterinary pests.

Size	50 mg
Shipping	dry ice
CAS Number	51-03-6
Molecular Formula	C₁₉H₃₀O₅
SMILES	CCCC1=C(COCCOCCOCCCC)C=C(OCO2)C2=C1
Molecular Weight	338,4
Formulation	A liquid
Purity	≥95%
Custom Code	2909.30
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.