Chlorothalonil

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Chlorothalonil

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Cat No: 24142

Biochemicals - Pesticides

Chlorothalonil is a broad-spectrum organochlorine fungicide that forms adducts with glutathione (GST; Item No. 10007461) and cysteine residues on enzymes leading to GST depletion and enzyme deactivation, respectively.{41822} In vitro, it inhibits the ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile

Correlated keywords:

1 1000 101963-73-9 1192 15 164 164SA 216082-57-4 231 2787 2787WP 342632-51-3 37223-69-1 404 404D 462093-27-2 500-SC 500SC 50SC 54 54D 54DB 6F 720 750 750PM 75WP 801 96 960 Agronil Barrack Blotch Bravo Bravonil Busan Chloronil Chlorothalonil Chlorthalonil Clortosip D DAC Daconil Dacosoil Dakoflo DB F Fongil Forturf Fungitrol Guarant Gwarant Hortyl Kabiguard Kavach L M M1 M15 Marincide Microban mildewcide N N96 NexGen Nopcocide Nuocide Optimist PI PM SA SC SD SD404 Sweep Termil Tetrachlorobenzene Thalonil TPN Tuff-Brite TuffBrite Ultrex Vanox Weather Stik Weatherstik WP YS Candida Colletotrichum Staphylococcus Bacillus Escherichia Pseudomonas Phytophthora

Product Overview:
Chlorothalonil is a broad-spectrum organochlorine fungicide that forms adducts with glutathione (GST; Item No. 10007461) and cysteine residues on enzymes leading to GST depletion and enzyme deactivation, respectively.{41822} In vitro, it inhibits the growth of C. albicans and C. orbiculare fungi, S. aureus and B. cereus Gram-positive bacteria, and E. coli and P. aeruginosa Gram-negative bacteria (MICs = 0.7, 5, 1.3, 0.7, 0.5, and 1.7 µg/ml, respectively).{41823,41824} In vivo, chlorothalonil (100 µg/ml) completely inhibits the growth of P. infestans, the tomato late blight pathogen, on tomato plants.{41825} It is toxic to aquatic organisms, including species of fish, crustaceans, molluscs, and algae with tenth percentile of toxicity values of 25.23, 40.59, 0.69, and 3.94 µg/L, respectively, as well as to other aquatic invertebrates.{41826} Chlorothalonil is carcinogenic in animal models and induces neoplasms in the forestomach and kidneys of rats when administered at a dose of 3.8 mg/kg per day, but it is not genotoxic.{41827} Formulations containing chlorothalonil have been used as fungicides in agriculture.

Size	100 mg
Shipping	dry ice
CAS Number	1897-45-6
Molecular Formula	C₈Cl₄N₂
SMILES	ClC1=C(C#N)C(Cl)=C(Cl)C(Cl)=C1C#N
Molecular Weight	265,9
Formulation	A solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.