?-Lindane

Confirm delete?

?-Lindane

Zoom

Cat No: 23952

Biochemicals - Ion Channel Modulation

γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.{37358} It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1?,2?,3?,4?,5?,6?-hexachloro-cyclohexane

Correlated keywords:

8007-42-9 8073-23-2 25897-48-7 53529-37-6 55963-79-6 Aalindan Aficide Agrocide-III WP Ameisenmittel Merck Aparasin Aphtiria Aplidal Arbitex Arcotal-S BBH Ben-Hex Benhexol Bentox-10 Bercema-Spritz-Lindan 50 ?-benzohexachloride BHC ?BHC benzene hexachloride Bexol Celanex Chloresene Codechine DBH Detmol Extract Devoran Dol Granule Drilltox-Spezial Aglukon ENT 7,796 ENT7,796 Entomoxan Esoderm Fenoform forte Forst-Nexen Gamacid Gamacide-20 Gamene Gammalin-20 Gammaterr Gammaxene Gammexane Gamoline Geobilan Geolin G3 Gexane Heclotox Hexa Hexachloran Hexachlorane Hexatin Hexaverm Hexicide Hexyclan Hilbeech Hortex Hungaria-L7 Inexit Jacutin Kanodane Kokotine Kwell Neo-Scabicidol Nexen-FB Nexit Stark Nexol-E Nicochloran Omnitox Ovadziak Owadziak PLK Pedraczak Pflanzol Prodactif Quellada Sang Scabecid Scabene Spritz-Rapidin Spritzlindane Spruehpflanzol Streunex TAP85 tap 85 Tri-6 Verindal Ultra Viton ?-hexachlorocyclohexane HCH HCC HCCH HGI Lasochron lendine lentox lidenal lindafor lindatox lindex lindosep lintox 3 linvur lorexane Mglawik Milbol 49 Mszycol 666 hexachlorobenzene GABA-A

Product Overview:
γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.{37358} It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, and 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively).{37359,37360} It binds to a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively).{37361} γ-Lindane blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively).{37362} It is toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively) and also kills head lice in vitro and inhibits hatching.{37361,37363}

Size	100 mg
Shipping	dry ice
CAS Number	58-89-9
Molecular Formula	C₆H₆Cl₆
SMILES	Cl[C@@H]1[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@@H]1Cl
Molecular Weight	290,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2902.90
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.