15-deoxy-?^12,14-Prostaglandin D₂-d₄

Biochemicals - Isotopically Labeled Standards

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Cat No: 19343

Biochemicals - Isotopically Labeled Standards

15-deoxy-Δ12,14-Prostaglandin D2-d4 (15-deoxy-Δ12,14-PGD2-d4) is an internal standard for the quantification of 15-deoxy-Δ12,14-PGD2 (Item No. 12700) by GC- or LC-MS. 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agoni...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

rac-(Z)-7-((1R,5S,E)-5-hydroxy-2-((E)-oct-2-en-1-ylidene)-3-oxocyclopentyl)hept-5-enoic-3,3,4,4-d4 acid

Correlated keywords:

GCMS LCMS Deuturium deuterated PGD DP 2 HEK 293 SRC1 PPAR ? L 1210

Product Overview:
15-deoxy-Δ12,14-Prostaglandin D2-d4 (15-deoxy-Δ12,14-PGD2-d4) is an internal standard for the quantification of 15-deoxy-Δ12,14-PGD2 (Item No. 12700) by GC- or LC-MS. 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}

Size	100 µg
Shipping	dry ice
CAS Number	2750534-91-7
Molecular Formula	C₂₀H₂₆D₄O₄
SMILES	O=C1/C([C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](O)C1)=C/C=C/CCCCC
Molecular Weight	338,5
Formulation	A solution in methyl acetate
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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