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15-deoxy-?12,14-Prostaglandin D2

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    15-<wbr/>deoxy-<wbr/>?<sup>12,14</sup>-<wbr/>Prostaglandin D<sub>2</sub>
  • 15-<wbr/>deoxy-<wbr/>?<sup>12,14</sup>-<wbr/>Prostaglandin D<sub>2</sub>
Cat No: 12700
Biochemicals - Lipids
Cayman

15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 9?-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid
Correlated keywords:
  • PPARs prostaglandins peroxisome proliferator-activated receptors 15-deoxy-DELTA12,14-PGD2 15-deoxy-.DELTA.12,14-PGD2 15-deoxy-d12,14-PGD2 leukemia cells cancer 15d-pgd2 L-1210 DP-2 HEK-293
Product Overview:
15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}
Size 500 µg
Shipping dry ice
CAS Number 85235-11-6
Molecular Formula C20H30O4
SMILES O=C1/C([C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1)=C/C=C/CCCCC
Molecular Weight 334,5
Formulation A solution in methyl acetate
Purity ≥95%
Custom Code 2937.50
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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