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BRD2 bromodomain 1 (human, recombinant)

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    BRD2 bromodomain 1 (human, recombinant)
  • BRD2 bromodomain 1 (human, recombinant)
Cat No: 11071
Proteins - More Proteins
Cayman

Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the bromodomain and extra-terminal (BET) family.{33144} It is ubiquitously expressed and localizes to the nucleus. BRD2 is composed of two N-terminal bromodomains (BD1 ...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • BRD 2 RING 3 RNF anti-viral SARS-CoV-2 SARSCoV2 covid-19 covid19 coronavirus corona virus
Product Overview:
Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the bromodomain and extra-terminal (BET) family.{33144} It is ubiquitously expressed and localizes to the nucleus. BRD2 is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple histone acetylation marks to the transcriptional regulation of target promoters, and an extra-terminal domain that mediates chromatin interactions.{33144,55056} BRD2 associates with transcription effector and regulator proteins, including RNA polymerase II, histone acetylases and deacetylases, and transcriptional co-activators and co-repressors to form a transcription complex that regulates the expression of genes involved in inflammation and cell proliferation.{33144,55055} BRD2 also binds to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein, a transmembrane protein involved in CoV virion assembly and pathogenesis of the related virus, SARS-CoV.{55024,53462,49521} The BD1 bromodomain of BRD2 contains four α-helices that form the binding site for the acetylated histone H4 tail.{55092} Point mutations in the BD1 bromodomain reduce the binding affinity of BRD2 for acetylated histone H4 lysine 12 (H4K12Ac), and a point mutation of tyrosine 154 (Y154F) abolishes the association between BRD2 and STAT3.{55092,55093} Cayman’s BRD2 bromodomain 1 (human, recombinant) protein can be used for ELISA, Western blot (WB), and binding assay applications.
Size 100 µg
Shipping dry ice
Formulation 50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM ?-mercaptoethanol
Purity ≥95% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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