p38 MAPK Monoclonal Antibody (Cl

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p38 MAPK Monoclonal Antibody (Clone 9F12)

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Cat No: 10011301

p38 mitogen-activated protein kinase (MAPK) is a member of the serine-threonine MAPK family that triggers many cellular processes including cell cycle, development, and apoptosis.{15420,15421} These kinases are activated by environmental stress signal...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

serine threonine serine-threonine cell cycles development apotosis kinases stress signals cytokines gene expression western blots immunoblotting immunocytochemisty ICC WB flow cytometry signal transduction signalling signaling blotting FC

Product Overview:
p38 mitogen-activated protein kinase (MAPK) is a member of the serine-threonine MAPK family that triggers many cellular processes including cell cycle, development, and apoptosis.{15420,15421} These kinases are activated by environmental stress signals such as osmotic shock, infection, and cytokines causing phosphorylation of p38 MAPK. This results in a phosphorylation cascade, activating transcription factors, and inducing gene expression.{15420,15424} p38 MAPK is widely expressed in heart, brain, skeletal muscle, platelets, and immune cells. Due to this distribution, p38 MAPK plays a role in cardiovascular disease, arthritis, and cancer.{15421,15422,1523,15424} It is mainly present in the cytosol, but can also be found in the nucleus after activation.{15421} Based on the amino acid sequence, the expected molecular weight of this protein is 41 kDa.

Size	1 ea
Shipping	dry ice
Host	Mouse
Antigen	human full length p38 MAPK
Clone	clone 9F12
Application(s)	WB, ICC, and flow cytometry
Formulation	200 µg IgG1 in 500 µl PBS, pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.