Capecitabine-d11

Confirm delete?

Capecitabine-d₁₁

Zoom

Cat No: 10010681

Biochemicals - Isotopically Labeled Standards

Capecitabine-d11 is intended for use as an internal standard for the quantification of capecitabine (Item No. 10487) by GC- or LC-MS. Capecitabine is a prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several e...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5'-deoxy-5-fluoro-N-[(pentyl-1,1,2,2,3,3,4,4,5,5,5-d11-oxy)carbonyl]-cytidine

Correlated keywords:

154361-50-9 deuterated deuterium 5FU MKN-45 COLO205 HCT-116 MCF7 Ro-09-1978 Ro-091978 Ro091978

Product Overview:
Capecitabine-d11 is intended for use as an internal standard for the quantification of capecitabine (Item No. 10487) by GC- or LC-MS. Capecitabine is a prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO 205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).

Size	1 mg
Shipping	dry ice
CAS Number	1132662-08-8
Molecular Formula	C₁₅H₁₁D₁₁FN₃O₆
SMILES	CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)C(O)C1O
Molecular Weight	370,4
Formulation	A crystalline solid
Purity	≥99% deuterated forms (d1-d11)
Custom Code	3822.19
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.