L-threo-Sphingosine (d18:1)

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L-threo-Sphingosine (d18:1)

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Cat No: 10010541

Biochemicals - Kinase Inhibitors

Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro-sphingosine occurs naturally. L-threo-Sphingosine C-18, an ana...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2S-amino-4E-octadecene-1,3S-diol

Correlated keywords:

D-erythro-sphingosine sphingolipids ceramides serines palmitoyltransferases protein kinases C cells proliferations cytoskeletal organization inhibitor inhibition inhibits PKCsSPTs

Product Overview:
Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro-sphingosine occurs naturally. L-threo-Sphingosine C-18, an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length.{15200} Addition of L-threo-Sphingosine C-18 to primary cultured cerebellar cells does not decrease serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, whereas under similar conditions D-erythro-sphingosine inhibits SPT activity.{15203}

Size	5 mg
Shipping	dry ice
CAS Number	25695-95-8
Molecular Formula	C₁₈H₃₇NO₂
SMILES	CCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO
Molecular Weight	299,5
Formulation	A crystalline solid
Purity	>98%
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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