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Simvastatin (sodium salt)

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    Simvastatin (sodium salt)
  • Simvastatin (sodium salt)
Cat No: 10010345
Biochemicals - Small Molecule Inhibitors
Cayman

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).{15312} Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively.{15310} Simvastatin suppresses TNF-induced NF...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (?R,?R,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-?,?-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt
Correlated keywords:
  • 79002-63-9 12009-77-6 121009-77-6 343252-47-1 atherosclerosis HMG-CoA reductase LDL LDL-c HDL HDL-c statins cholesterol hearts diseases CVD zetia ezetimibe vytorin inegy TNF-? TNF? NF-?B NF?B apoptosis cancers inhibitors inhibits inhibition enzymes dogs humans leukemia cells MDAMB231 MDAMB MCF7
Product Overview:
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).{15312} Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively.{15310} Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells.{15363} It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells.{62465} Formulations containing simvastatin have been used in the treatment of dyslipidemias.
Size 1 mg
Shipping dry ice
CAS Number 101314-97-0
Molecular Formula C25H39O6 • Na
SMILES C[C@@H]1C[C@H](OC(C(C)(CC)C)=O)C2C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C1.[Na+]
Molecular Weight 458,6
Formulation A crystalline solid
Purity ≥98%
Custom Code 2915.60
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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