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Mouse Anti-Type II Collagen IgG Assay Kit (bovine)

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    Mouse Anti-<wbr/>Type II Collagen IgG Assay Kit (bovine)
  • Mouse Anti-<wbr/>Type II Collagen IgG Assay Kit (bovine)
Cat No: 500410
Assay Kits - Elisa
Price is excluding VAT and does not include packaging neither shipping

Collagen-induced arthritis (CIA) is an experimental autoimmune disease that is widely used as a model of human rheumatoid arthritis (RA) in the study of the pathogenic mechanisms of this disease and for testing potential therapeutics. Circulating leve...

: 96 wells

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Territorial Availability: Available through Bertin Technologies only in Europe
Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay
Correlated keywords:
  • EIAs enzymes kits assays measures measurements immunometric enzymes immunoassays collagen-induced arthritis CIA autoimmune diseases human rheumatoid RA pathogenic therapeutics mouse rat murine nonhuman primates immunization heterologous CII proteins articular cartilage autoimmune-mediated polyarthritis collagen-specific T cells antibody autologous inflammation cascade pro-inflammatory cytokines chemokines degrading Type II plasma serum
Product Overview:
Collagen-induced arthritis (CIA) is an experimental autoimmune disease that is widely used as a model of human rheumatoid arthritis (RA) in the study of the pathogenic mechanisms of this disease and for testing potential therapeutics. Circulating levels of anti-type II collagen antibody are strongly associated with the development of arthritis and can be used as a biomarker of CIA. Cayman’s Mouse Anti-Type II Collagen IgG Assay is an immunometric (i.e., sandwich) assay which can be used to measure anti-type II collagen antibody in plasma or serum without prior sample purification. This kit uses a bovine collagen-coated plate and an affinity-purified polyclonal antibody isolated from mice with CIA as a standard. This standard provides the most accurate measurement of anti-CII concentration in experimental plasma samples. One unit of standard in this assay is approximately equal to 1 ng of IgG protein. The standard curve spans the range of 15.6-1,000 U/ml, with an LLOQ of 15.6 U/ml.
Size 96 wells
Shipping wet ice
Stability Store at 4 degrees; shelf life 180 days
Custom Code 3822.00
UNSPSC code 41116104

Stuart, J.M., Townes, A.S., and Kang, A.H. Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. J Clin Invest 63(3) 673-683 (1982).

Terato, K., Hasty, K.A., Cremer, M.A., et al. Collagen-indu

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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