Mouse Anti-Type II Collagen IgG

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Mouse Anti-Type II Collagen IgG Assay Kit (bovine)

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Cat No: 500410

Assay Kits - Elisa

Collagen-induced arthritis (CIA) is an experimental autoimmune disease that is widely used as a model of human rheumatoid arthritis (RA) in the study of the pathogenic mechanisms of this disease and for testing potential therapeutics. Circulating leve...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

EIAs enzymes kits assays measures measurements immunometric enzymes immunoassays collagen-induced arthritis CIA autoimmune diseases human rheumatoid RA pathogenic therapeutics mouse rat murine nonhuman primates immunization heterologous CII proteins articular cartilage autoimmune-mediated polyarthritis collagen-specific T cells antibody autologous inflammation cascade pro-inflammatory cytokines chemokines degrading Type II plasma serum

Product Overview:
Collagen-induced arthritis (CIA) is an experimental autoimmune disease that is widely used as a model of human rheumatoid arthritis (RA) in the study of the pathogenic mechanisms of this disease and for testing potential therapeutics. Circulating levels of anti-type II collagen antibody are strongly associated with the development of arthritis and can be used as a biomarker of CIA. Cayman’s Mouse Anti-Type II Collagen IgG Assay is an immunometric (i.e., sandwich) assay which can be used to measure anti-type II collagen antibody in plasma or serum without prior sample purification. This kit uses a bovine collagen-coated plate and an affinity-purified polyclonal antibody isolated from mice with CIA as a standard. This standard provides the most accurate measurement of anti-CII concentration in experimental plasma samples. One unit of standard in this assay is approximately equal to 1 ng of IgG protein. The standard curve spans the range of 15.6-1,000 U/ml, with an LLOQ of 15.6 U/ml.

Size	96 wells
Shipping	wet ice
Custom Code	3822.19
UNSPSC code	41116104

Stuart, J.M., Townes, A.S., and Kang, A.H. Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. J Clin Invest 63(3) 673-683 (1982).

Terato, K., Hasty, K.A., Cremer, M.A., et al. Collagen-indu

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.