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1,8-ANS

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    1,8-<wbr/>ANS
  • 1,8-<wbr/>ANS
Cat No: 10010219
Cayman

1,8-ANS is a fluorescent dye that binds with high affinity to hydrophobic surfaces of proteins.{14908,14913} 1,8-ANS has an excitation maximum of 350 nm. It has an emission maximum of 520 nm when free in solution but undergoes a blue shift with an inc...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 8-(phenylamino)-1-naphthalenesulfonic acid
Correlated keywords:
  • FABP FABP1 FABP3 FABP4 FABP5
Product Overview:
1,8-ANS is a fluorescent dye that binds with high affinity to hydrophobic surfaces of proteins.{14908,14913} 1,8-ANS has an excitation maximum of 350 nm. It has an emission maximum of 520 nm when free in solution but undergoes a blue shift with an increase in fluorescence intensity when bound to protein; for example, when bound to intestinal fatty acid binding protein (FABP2) it has emission maxima of 468-477 nm. 1,8-ANS binds to low polarity regions of protein surfaces making it well suited for determining the affinity of hydrophobic ligands to their corresponding binding proteins, such as the binding of free fatty acids to FABPs.{14908,14913,14912} 1,8-ANS binds to FABP2 with a Kd value of approximately 9.7 µM at 24.5°C.{14913}
Size 5 g
Shipping dry ice
CAS Number 82-76-8
Molecular Formula C16H13NO3S
SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12
Molecular Weight 299,3
Formulation A crystalline solid
Purity ≥95%
Custom Code 2930.90
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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