GSK3? (Phospho-Ser9) Polyclonal

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GSK3? (Phospho-Ser⁹) Polyclonal Antibody

Cat No: 10009374

Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity.{60859,60860} It is ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

antibodies proteins diseases antibodies antisera antiserum WB western blots blotting serine/threonine kinases regulation regulates signaling pathways GSK3a GSK3alpha GSK3.alpha. GSK3b GSK3beta inhibitors inhibition inhibits insulin Wnt Ser9 phosphorylation phospho-specific immunoblotting GSK-3?

Product Overview:
Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity.{60859,60860} It is composed of an N-terminal β-strand domain, a kinase domain, and a C-terminal α-helical domain.{60861} GSK3β is constitutively active, ubiquitously expressed, and localizes predominantly to the cytosol but is also found in the nucleus and mitochondria.{60860,60862} It is inhibited by phosphorylation at serine 9 (Ser9), which is mediated by a variety of kinases, including PKA, PKB, and Akt, and has roles in insulin, growth factor, and Wnt signaling pathways.{60860} GSK3β is involved in several pathophysiological conditions, such as diabetes, cancer, inflammation, and neurological or psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and bipolar disorder.{60862,60859} Levels of GSK3β (phospho-Ser9) are decreased in the hippocampus and prefrontal cortex in a rat model of memory impairment and are rescued by lithium.{62477} The overexpression of GSK3β with low levels of Ser9 phosphorylation is associated with a poor prognosis in patients with pancreatic ductal carcinoma (PDAC).{62478} However, GSK3β (phospho-Ser9) levels are increased in cisplatin-resistant ovarian cancer cells in vitro and in skin cancer tissues from patients with squamous cell carcinoma.{62476} Cayman's GSK3β (Phospho-Ser9) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes GSK3β (phospho-Ser9) at ~46 kDa from rat and mouse samples.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Phosphopeptide corresponding to rat GSK3? (phospho-Ser9)
Application(s)	WB
Formulation	Peptide affinity-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

GSK3? (Phospho-Ser9) Polyclonal Antibody