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Trifluoperazine (hydrochloride)

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    Trifluo<wbr/>perazine (hydro<wbr>chloride)
  • Trifluo<wbr/>perazine (hydro<wbr>chloride)
Cat No: 15068
Biochemicals - Ion Channel Modulation
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine, dihydrochloride
Correlated keywords:
  • 117-89-5 phenothiazine anti-adrenergic anti adrenergic antiadrenergic dopaminergic antidopaminergic anti-dopaminergic typical antipsychotic antagonists adrenergic α1 receptors dopamines D2-like receptors calmodulin calcium-binding calsequestrin CSQ D2 like calcium binding binds binders agents phenothiazine calsequestrin eskazine eskazinyl fluoperazine jatroneural modalina SKF 5019 SKF5019 SKF-5019 stelazine TFP terfluzine trazine trifluoperazine trifluoperazine trifluoroperazine triftazin triphthasine triphthazine tryptazine HCl signals transduction neurosciences
Product Overview:
Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Size 1 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 440-17-5
Molecular Formula C21H24F3N3S • 2HCl
SMILES CN(CC1)CCN1CCCN2C3=C(C=CC(C(F)(F)F)=C3)SC4=CC=CC=C42.Cl.Cl
Molecular Weight 480,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.59
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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