Flavopiridol (hydrochloride)

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Cat No: 10009197

Biochemicals - Kinase Inhibitors

Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively).{23163} It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value o...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, monohydrochloride

Correlated keywords:

358739-39-6 146426-40-6 arthritis cyclin-dependent CDKs positive transcriptions elongation factors P-TEFb PTEFb Cdk9 Cdk-9 9 nine prevents prevention HIV-1 HIV1 one humans immunodeficiency virus isoforms epidermal growths factors receptors EGFRs proteins A PKA therapy joints synovial hyperplasia destruction collagen HMR-1275 HMR1275 L86-8275 L868275 L8 8275 HL-275 HL275 RNA subunits polymerases II

Product Overview:
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively).{23163} It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM.{23157} Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK239T cells (IC50 = In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model.{23163} It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.{23156}

Size	5 mg
Shipping	dry ice
CAS Number	131740-09-5
Molecular Formula	C₂₁H₂₀ClNO₅ • HCl
SMILES	ClC1=C(C(OC2=C3C(O)=CC(O)=C2[C@H]4CCN(C)C[C@H]4O)=CC3=O)C=CC=C1.Cl
Molecular Weight	438,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.