Dinaciclib

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Dinaciclib

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Cat No: 14707

Biochemicals - Kinase Inhibitors

Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2S-piperidineethanol

Correlated keywords:

1000697-89-1 Sch 727965 Sch727965 Sch-727965 SCH 727965 anticancers anti-cancers anti cancers cyclin-dependent pan CDKs pan-CDK inhibitors CDK1 CDK2 CDK5 CDK9 flavopiridol cyclin dependent kinases CDK-1 CDK-2 CDK-5 CDK-9 1 2 5 9 one two five nine in vitro inhibits inhibitions tumors growths ovarian carcinoma potent 1000697-89-1 DNA synthesis

Product Overview:
Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively.{24650} Compared to the pan-CDK inhibitor flavopiridol (Item No. 10009197), dinaciclib is an equally potent inhibitor of CDK1 and CDK9 but a 12-14-fold more potent inhibitor of CDK2 and CDK5.{24650} It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC50 value of 4 nM.{24650} At 5 mg/kg it prevents tumor growth by 50% in an A2780 ovarian carcinoma mouse xenograft model and is active against a broad spectrum of human tumor cell lines in vitro (IC50s = 7-17 nM).{24650}

Size	5 mg
Shipping	dry ice
CAS Number	779353-01-4
Molecular Formula	C₂₁H₂₈N₆O₂
SMILES	OCC[C@H]1N(C2=NC3=C(CC)C=NN3C(NCC4=CC=C[N+]([O-])=C4)=C2)CCCC1
Molecular Weight	396,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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