?,?-Methyleneadenosine 5'-tripho

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?,?-Methyleneadenosine 5'-triphosphate (sodium salt)

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Cat No: 10008956

Biochemicals - Ion Channel Modulation

α,β-Methyleneadenosine 5'-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5'-[hydrogen P-[[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] adenosine, trisodium salt

Correlated keywords:

biochemical receptor agonist receptor biochemistry signal transduction intracellular signaling 7292-42-4 stable ATP analog P2X1 P2X3 agonist phosphonic methylene replacement P2X purinoceptor desensitization desensitize antagonist-like effect interaction kinase protein bind inhibitor inhibit adenylate cyclase calcium-dependent

Product Overview:
α,β-Methyleneadenosine 5'-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors.{27693,27688,27691,27687} Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP.{27689} αβ-methylene ATP is used as a stable analog of ATP (Item No. 14498) to study the interaction of ATP with kinases and other proteins.{27690,27694} It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM).{27692,27695}

Size	1 mg
Shipping	dry ice
CAS Number	1343364-54-4
Molecular Formula	C₁₁H₁₅N₅O₁₂P₃ • 3Na
SMILES	O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(CP(OP(O)([O-])=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+]
Molecular Weight	571,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2835.31
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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