PtdIns-(3,4,5)-P3 (1,2-dihexanoy

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PtdIns-(3,4,5)-P₃ (1,2-dihexanoyl) (ammonium salt)

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Cat No: 10008390

Biochemicals - Lipids

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{16567,16566} PtdIns-(3,4,5)-P3, also known as PIP3, is...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(1,2R-dihexanoylphosphatidyl)inositol-3,4,5-triphosphate, tetraammonium salt

Correlated keywords:

phosphatidylinositols cell signalling pleckstrin homology protein binding PIP3 PtdIns phospholipid signal transduction C6 C-6

Product Overview:
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{16567,16566} PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC).{13721} Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains.{5241}{8674} Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking.{16565} PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media.

Size	100 µg
Shipping	dry ice
CAS Number	799268-62-5
Molecular Formula	C₂₁H₄₂O₂₂P₄ • 4NH₃
SMILES	O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(OC[C@H](OC(CCCCC)=O)COC(CCCCC)=O)=O
Molecular Weight	838,6
Formulation	A lyophilized powder
Purity	≥98%
Custom Code	2906.13
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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