nor-NOHA (acetate)

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nor-NOHA (acetate)

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Cat No: 10006861

Biochemicals - Small Molecule Inhibitors

L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2S-amino-4-[[(hydroxyamino)iminomethyl]amino]-butanoic acid, diacetate

Correlated keywords:

spibio spi-bio buffers rat liver inhibitor inhibitors murine macrophags cells nitric oxides arginases

Product Overview:
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA.{13098} It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM.{13096} nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.{13095, 13100}

Size	1 mg
Shipping	dry ice
CAS Number	1140844-63-8
Molecular Formula	C₅H₁₂N₄O₃ • 2C₂H₄O₂
SMILES	N/C(N([H])CC[C@H](N)C(O)=O)=N\O.CC(O)=O.CC(O)=O
Molecular Weight	296,3
Formulation	A lyophilized powder
Purity	≥97%
Custom Code	2918.99
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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