QNZ - C22H20N4O - Bertin Bioreagent

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QNZ

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Cat No: 10006734

Biochemicals - Small Molecule Inhibitors

Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human J...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N4-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine

Correlated keywords:

inhibits inhibitors inhibitions NF kB NF-kB NF-.kappa.B nuclear factors transcription proinflammatory cytokines TNFa TNF.alpha. interleukins IL-1b IL-1.beta. IL-6 IL-8 activation Jurkat cells LPS lipopolysaccharides murine splenocytes in vivo edema carrageenin rat hind paw NF-kappaB nfkb nf-kb NF-.kappa.B genes regulations

Product Overview:
Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.{12722}

Size	500 µg
Shipping	dry ice
CAS Number	545380-34-5
Molecular Formula	C₂₂H₂₀N₄O
SMILES	NC1=CC2=C(N=CN=C2NCCC3=CC=C(OC4=CC=CC=C4)C=C3)C=C1
Molecular Weight	356,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2942.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.