CAY10485

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CAY10485

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Cat No: 10006482

Biochemicals - Small Molecule Inhibitors

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.{10960,11758} CAY104...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[3-(3,4-dihydroxyphenyl)-1-oxopropyl]-L-aspartic acid, bis(phenylmethyl) ester

Correlated keywords:

atherosclerosis antioxidants dihydrocinnamic acids LDLs low density lipoproteins cholesterols acyl-coenzyme A: cholesterol acyltransferase-1 catalyzes esters ACAT-1 ACAT-2 low density lipoproteins oxidations ACAT1 ACAT2

Product Overview:
Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.{10960,11758} CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively.{12441} It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 µM.{12441}

Size	5 mg
Shipping	dry ice
CAS Number	615264-62-5
Molecular Formula	C₂₇H₂₇NO₇
SMILES	O=C(CCc1ccc(O)c(O)c1)N[C@@H](CC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Molecular Weight	477,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2942.00
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.