Berberine (chloride)

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Cat No: 10006427

Biochemicals - Natural Products

Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.{57563,25000,37022,49318,12390} It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae in th...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride

Correlated keywords:

2086-83-1 natural alkoloid hypocholesterolemic activity berberidaceaen medicine antiprotozoal antidiahreal agents reduces total cholesterol LDLR low-density lipoproteins triglycerides high fat diet LDL-receptors proteins mRNA levels hepatocytes serum atherosclerosis NSC646666 NSC163088

Product Overview:
Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.{57563,25000,37022,49318,12390} It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae in the exponential growth phase, respectively, when used at a concentration of 50 µg/ml.{25000} Berberine is active against the S. aureus strains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both).{37022} It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.{49318} Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.{12390}

Size	1 g
Shipping	dry ice
CAS Number	633-65-8
Molecular Formula	C₂₀H₁₈NO₄ • Cl
SMILES	COC1=C2C(C=C3[N+](CCC4=C3C=C5C(OCO5)=C4)=C2)=CC=C1OC.[Cl-]
Molecular Weight	371,8
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2942.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.