Hormone-Sensitive Lipase Blockin

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Hormone-Sensitive Lipase Blocking Peptide

Cat No: 10006372

Antibodies - Blocking Peptides

To be used in conjunction with Cayman’s HSL Polyclonal Antibody (Item No. 10006371) to block protein-antibody complex formation during immunochemical analysis of HSL Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglyc...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

peptides proteins antibodies signaling signalling WB western blots blotting ICC immunocytochemistry catalyses hydrolysis of tri- di- monoacylglycerols cholesterol esters mobilizes fatty acids primary source energy mammals enzyme expressed adipose tissues stearidonic steroidgenesis spermatogenesis foam cell formation atherosclerosis diabetic pathology human cDNA isoforms testis mRNA mouse murine macrophages testicular ram seminal vesicles

Product Overview:
To be used in conjunction with Cayman’s HSL Polyclonal Antibody (Item No. 10006371) to block protein-antibody complex formation during immunochemical analysis of HSL Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters and thus mobilizes fatty acid and provides a primary source of energy in mammals.{13168} The enzyme is highly expressed in adipose tissue and steroidogenic tissues, and less abundantly in skeletal muscle, heart, brain, pancreatic beta cells, adrenal gland, ovaries, testes, and macrophages. Its presence in various tissues indicates the enzyme plays diverse roles including those in steroidogenesis and spermatogenesis, foam cell formation in atherosclerosis, and diabetic pathology.{13168,13167} Human HSL cDNA encodes a 775 amino acid protein with an estimated molecular size of 84 kDa.{13169} A second, larger isoform encoded by a unique testis mRNA was later identified.{13171,13166} Cayman’s HSL Polyclonal Antibody detects the enzyme at 86 kDa by western blotting from adipose tissue and mouse macrophage whereas it detects mainly the testicular isoform at approximately 130 kDa from ram seminal vesicle, HEK293 and THP-1 cells.

Size	1 ea
Shipping	dry ice
Formulation	200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Custom Code	3504.00
UNSPSC code	41105329

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.