Hormone-Sensitive Lipase Polyclo

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Hormone-Sensitive Lipase Polyclonal Antibody

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Cat No: 10006371

Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters and thus mobilizes fatty acid and provides a primary source of energy in mammals.{13168} The enzyme is highly expressed in adipo...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

proteins antibodies antisera antiserum WB western blots blotting IHC immunohistochemistry ICC immunocytochemistry catalyses hydrolysis of tri- di- monoacylglycerols cholesterol esters mobilizes fatty acids primary source energy mammals enzyme expressed adipose tissues stearidonic steroidgenesis spermatogenesis foam cell formation atherosclerosis diabetic pathology human cDNA isoforms testis mRNA mouse murine macrophages testicular ram seminal vesicles triacylglycerols diacylglycerols atherosclerosis

Product Overview:
Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters and thus mobilizes fatty acid and provides a primary source of energy in mammals.{13168} The enzyme is highly expressed in adipose tissue and steroidogenic tissues, and less abundantly in skeletal muscle, heart, brain, pancreatic beta cells, adrenal gland, ovaries, testes, and macrophages. Its presence in various tissues indicates the enzyme plays diverse roles including those in steroidogenesis and spermatogenesis, foam cell formation in atherosclerosis, and diabetic pathology.{13168,13167} Human HSL cDNA encodes a 775 amino acid protein with an estimated molecular size of 84 kDa.{13169} A second, larger isoform encoded by a unique testis mRNA was later identified.{13171,13166} Cayman’s HSL Polyclonal Antibody can be used for Western blot applications. The antibody recognizes HSL at 86 kDa from human, mouse, and rat samples.

Size	500 µl
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide from the C-terminal region of human HSL receptor
Application(s)	WB
Formulation	Peptide affinity-purified IgG
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.