Renin (human, recombinant)

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Cat No: 10006217

Proteins - Enzymes

Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone.{57726} It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activi...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

aspartyl protease kidney juxtaglomerular cell macula densa angiotensinogen angiotensin I

Product Overview:
Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone.{57726} It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activity. It is formed from prorenin, a zymogen found primarily in the juxtaglomerular cells in the kidney, by proteolytic removal of its autoinhibitory domain.{12970,57727} Renin catalyzes the conversion of angiotensinogen to angiotensin I, which is the first and rate-limiting step of the renin-angiotensin system (RAS) responsible for regulating blood pressure.{57727} When blood pressure is low, renin secretion is increased and the RAS is activated, which increases arterial vasoconstriction and sodium resorption to maintain blood pressure at homeostatic levels.{13007} Deletion or substitution of the leucine in position 16 of REN, the gene encoding renin, that reduce or eliminate renin biosynthesis are associated with multiple inflammatory diseases, including chronic kidney failure and early-onset hyperuricemia.{57728} Cayman's Renin (human, recombinant) protein can be used for enzyme assay and Western blot applications.

Size	25 µg
Shipping	dry ice
Formulation	50 mM Tris, pH 8.0, with 150 mM NaCl and 5% glycerol
Purity	≥85% estimated by SDS-PAGE
Custom Code	3507.90
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.