DMPO Nitrone Adduct Polyclonal A

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DMPO Nitrone Adduct Polyclonal Antiserum

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Cat No: 10006170

DMPO is a spin trap that reacts with oxygen-, nitrogen-, sulfur-, and carbon-centered radicals.{2717,10527,3851} It also reacts with DNA base- and amino acid-derived radicals to form DNA- and protein-DMPO nitroxone adducts, respectively, which rapidly...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

proteins radicals EPR spin trap antibodies antisera antiserum western blots blotting WB ELISA enzyme-linked immunosorbent immunoassays adducts electrons paramagnetics resonance antibodies antibody immunodetection immunoblotting assays

Product Overview:
DMPO is a spin trap that reacts with oxygen-, nitrogen-, sulfur-, and carbon-centered radicals.{2717,10527,3851} It also reacts with DNA base- and amino acid-derived radicals to form DNA- and protein-DMPO nitroxone adducts, respectively, which rapidly decay to form DMPO-nitrone adducts.{55239} DMPO-nitrone adducts were previously detected using electron paramagnetic resonance (EPR), however, immunochemical detection allows a higher level of sensitivity and throughput with greatly reduced sample consumption.{55239,12294,55240} Cayman’s DMPO Nitrone Adduct Polyclonal Antiserum can be used for Western blot, immunocytochemistry, and ELISA applications. The antiserum recognizes various DMPO-nitrone adducts, including DNA and protein species.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	5,5-dimethyl-2-(8-octanoic acid)-1-pyrroline N-oxide coupled to ovalbumin
Application(s)	ELISA, ICC, and WB
Formulation	100 µl of rabbit anti-DMPO nitrone adduct polyclonal antiserum
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.