Doppel Polyclonal Antibody

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Cat No: 10005517

Doppel is a homolog of the cellular prion protein. Like prion protein, doppel has two N-linked oligosaccharides, and is presented on the cell surface via a glycosylphosphatidylinositol anchor.{11663} Unlike prion protein, it lacks the conformationally...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

immunohistochemistry western blot Pr-PLP

Product Overview:
Doppel is a homolog of the cellular prion protein. Like prion protein, doppel has two N-linked oligosaccharides, and is presented on the cell surface via a glycosylphosphatidylinositol anchor.{11663} Unlike prion protein, it lacks the conformationally plastic and octapeptide repeat domains.{11604} The primary physiological role of doppel protein remains to be determined, but there is some evidence suggesting that cell surface prion protein can antagonize the toxic effect of doppel expressed in the central nervous system.{11663} In addition, the protein may play a major role in human male fertility, given its expression on both sertoli cells and spermatozoa.{11666} Doppel is differentially glycosylated, causing it to migrate at multiple sizes on SDS-PAGE.{11663} Cayman’s Doppel Polyclonal Antibody can be used for immunohistochemistry and Western blot applications. The antibody recognizes Doppel at 19 kDa (nonglycosylated) and 25 kDa (monoglycosylated) from human, mouse, and rat samples.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide from an internal region of human Doppel
Application(s)	IHC and WB
Formulation	500 µl of peptide affinity-purified peptide
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.