Cytokeratin Monoclonal Antibody

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Cytokeratin Monoclonal Antibody (Clone C-11)

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Cat No: 10004600

Cytokeratins (CKs) are intermediate filaments proteins and members of the cytokeratin protein family.{59484,15723,58664} The cytokeratin family is composed of at least 20 unique gene products, which fall into two categories: type I acidic cytokeratins...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

cytokeratins pan-cytokeratins antibodies antiserum antisera isoforms nonhelical CK C11

Product Overview:
Cytokeratins (CKs) are intermediate filaments proteins and members of the cytokeratin protein family.{59484,15723,58664} The cytokeratin family is composed of at least 20 unique gene products, which fall into two categories: type I acidic cytokeratins, CK9-CK20, and type II neutral-basic cytokeratins, CK1-CK8.{15723} Each cytokeratin is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively.{15723,58664} Cytokeratins are major structural proteins expressed in epithelial cells and localized to the cytoplasm where they form heterozygous type I-type II pairs.{59484,15740} They primarily function to protect epithelial cells from mechanical and non-mechanical stresses that induce cell rupture and death.{15273} Cytokeratins have additional isoform- and tissue-specific functions, including the modulation of protein synthesis and cell size during epithelial growth and roles in skin pigmentation. Cayman’s Cytokeratin Monoclonal Antibody (Clone C-11) can be used for flow cytometry (FC), immunofluorescence (IF), immunohistochemistry (IHC), and Western blot (WB) applications. This antibody recognizes cytokeratins 4, 5, 6, 8, 10, 13, and 18 from human samples.

Size	1 ea
Shipping	wet ice
Host	Mouse
Clone	C-11
Isotype	IgG1
Application(s)	FC, IF, IHC, and WB
Formulation	100 ?g of ammonium sulfate-purified IgG
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.