12(S)-HETE-19,20-alkyne

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Cat No: 9001937

12(S)-HETE (Item No. 34570) is the predominant lipoxygenase product of mammalian platelets.{498} It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.{591,880} 12(S)-HETE-19,20-alkyne is a form of 1...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(S,5Z,8Z,10E,14Z)-12-hydroxyicosa-5,8,10,14-tetraen-19-ynoic acid

Correlated keywords:

1621073-95-712-HETEs 12S-HETEs 12(S)-HETEs 12(S)HETEs 12HETE 12-HETEs 12S-HETE-19,20-alkyne 12(S)HETE19,20alkyne 12HETE1920alkyne 12 HETEs 19 20

Product Overview:
12(S)-HETE (Item No. 34570) is the predominant lipoxygenase product of mammalian platelets.{498} It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.{591,880} 12(S)-HETE-19,20-alkyne is a form of 12(S)-HETE with an ω-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions, to tag 12(S)-HETE with fluorescent or biotinylated labels for analysis of its metabolism and biological activity.{17991,17992}

Size	25 µg
Shipping	dry ice
Molecular Formula	C₂₀H₂₈O₃
SMILES	C#CCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O
Molecular Weight	316,4
Formulation	A solution in ethanol
Purity	≥97%
Custom Code	2916.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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