Propionyl-L-carnitine (chloride)

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Cat No: 9001873

Biochemicals - Lipids

Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 1401...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-carboxy-N,N,N-trimethyl-2R-(1-oxopropoxy)-1-propanaminium, monochloride

Correlated keywords:

99581-18-7 20064-19-1 32886-?08-?1 113817-?31-?5 Dromos Levocarnitine propionate hydrochlorides Hcl ST 261 carnitine fatty acids mitochondrial metabolism cardiovascular diseases free radicals scavengers ST261 ST-261 propinyl carnitine chlorides natural acetyltransferases energy muscles citric cycles flux pyruvate dehydrogenases derivatives cardiology ischemic

Product Overview:
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto-prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}

Size	25 mg
Shipping	dry ice
CAS Number	119793-66-7
Molecular Formula	C₁₀H₂₀NO₄ • Cl
SMILES	C[N+](C)(C)C[C@@H](CC(O)=O)OC(CC)=O.[Cl-]
Molecular Weight	253,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.