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(R)-(?)-Linoleyl-2'-Hydroxy-1'-Propylamide

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    (R)-<wbr/>(?)-<wbr/>Linoleyl-<wbr/>2'-<wbr/>Hydroxy-<wbr/>1'-<wbr/>Propylamide
  • (R)-<wbr/>(?)-<wbr/>Linoleyl-<wbr/>2'-<wbr/>Hydroxy-<wbr/>1'-<wbr/>Propylamide
Cat No: 9001234
Biochemicals - Lipids
Cayman

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinit...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-((R)-2-hydroxypropyl)octadeca-9Z,12Z-dienamide
Correlated keywords:
  • 64012-03-9 LOEA NAE ethanolamides acylethanolamines homologs AEA hydroxypropylamide linoleoyl
Product Overview:
N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10, 25 μM for CB1, CB2, respectively) and inhibits voltage-gated K+ channels.{7422,13859} LOEA also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 μM) and is hydrolyzed by FAAH.{7251,3922} (R)-(−)-Linoleyl-2’-hydroxy-1’-propylamide is a homolog of LOEA which is characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce R-2 methanandamide (Item No. 90074) imparts diminished affinity for the CB receptor as well as reduced metabolic stability.{1092} The physiological actions of this compound have not been evaluated.
Size 1 mg
Shipping dry ice
Molecular Formula C21H39NO2
SMILES CCCCC/C=C\C/C=C\CCCCCCCC(NC[C@@H](C)O)=O
Molecular Weight 337,5
Formulation A solution in ethanol
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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