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?-Nicotinamide Mononucleotide

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    ?-<wbr/>Nicotinamide Mono<wbr/>nucleotide
  • ?-<wbr/>Nicotinamide Mono<wbr/>nucleotide
Cat No: 16411
Biochemicals - More Biochemicals

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1...


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Territorial Availability: Available through Bertin Technologies only in France
  • 3-(aminocarbonyl)-1-(5-O-phosphono-?-D-ribofuranosyl)-pyridinium, inner salt
Correlated keywords:
  • 27626-81-9 1140909-84-7 intermediate biosynthesis nicotinamide adenine dinucleotide NAD+ Nicotinamide phosphoribosyltransferase Nampt visfatin glucose insulin metabolism metabolic disease type 2 diabetes biochemical syndrome obesity ?-NMN ?NMN catalyze condensation 5-phosphoribosyl-1-pyrophosphate adenyltransferase biosynthesis glucose-stimulated secretion mouse mice model cell function ameliorate intolerance high-fat diet-induced level ribonucleoside 5'-phosphate ribotide ?-D-NMN ribose monophosphate
Product Overview:
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.{19182} At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.{19185} Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.{20366}
Size 10 mg
Shipping dry ice
CAS Number 1094-61-7
Molecular Formula C11H15N2O8P
SMILES O[C@H]1[C@@H](O)[C@H]([N+]2=CC(C(N)=O)=CC=C2)O[C@@H]1COP(O)([O-])=O
Molecular Weight 334,2
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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