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4-hydroxy Nonenal Glutathione-d3 (trifluoroacetate salt)

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    4-hydroxy Nonenal Glutathione<wbr/>-d<sub>3</sub> (trifluoro<wbr/>acetate salt)
  • 4-hydroxy Nonenal Glutathione<wbr/>-d<sub>3</sub> (trifluoro<wbr/>acetate salt)
Cat No: 9000876
Biochemicals - Isotopically Labeled Standards
Cayman

4-hydroxy Nonenal Glutathione-d3 (4-HNE-GSH-d3 (trifluoroacetate salt) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE-GSH (trifluoroacetate salt) by GC- or...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • L-y-glutamyl-S-[(3S)-tetrahydro-5-hydroxy-2-pentyl-3-furanyl]-L-cysteinyl-glycine-11,11,11-d3, trifluoroacetate salt
Correlated keywords:
  • oxidative stress lipids peroxidation 4-hydroxy nonenal 4-HNE deuterateds GSH-HNE internal standards mass spectrometry HNE-GSH-d3 deuteriums GC/MS LC/MS LC-MS MS
Product Overview:
4-hydroxy Nonenal Glutathione-d3 (4-HNE-GSH-d3 (trifluoroacetate salt) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE-GSH (trifluoroacetate salt) by GC- or LC-mass spectrometry. 4-hydroxy-Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.{869,1103} 4-HNE-GSH is a major adduct formed by the reaction of 4-HNE with GSH.{18611,7334,18610,18731} 4-HNE-GSH levels in liver, plasma, or isolated cells can serve as biomarkers for oxidative stress.{18729} The trapping of 4-HNE by glutathione to give HNE-GSH prevents the formation of DNA adducts with 4-HNE.{1670,18730} In human polymorphonuclear leukocytes, HNE-GSH is metabolized to 1,4-dihydroxynonene glutathione (DHN-GSH), 4-hydroxynonenoic acid glutathione (HNA-GSH), and 4-hydroxy nonenal mercapturic acid (HNE-MA).{18611}
Size 50 µg
Shipping dry ice
Molecular Formula C19H30D3N3O8S • CF3COOH
SMILES O=C(NCC(O)=O)[C@H](CS[C@H]1CC(O)OC1CCCCC([2H])([2H])[2H])NC(CC[C@@H](N)C(O)=O)=O.FC(F)(C(O)=O)F
Molecular Weight 580,6
Formulation A lyophilized powder
Purity ≥99% deuterated forms (d1-d3)
Custom Code 3822.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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