13,14-dihydro Prostaglandin E₁-d₄

Biochemicals - Isotopically Labeled Standards

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Cat No: 9000281

Biochemicals - Isotopically Labeled Standards

13,14-dihydro Prostaglandin E1-d4 (13,14-dh PGE1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh PGE1 by GC- or LC-mass spectrometry. 13,14-dh PGE1 ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-oxo-11?,15S-dihydroxy-prostan-1-oic-3,3,4,4-d4 acid

Correlated keywords:

PGE0 metabolites 13,14-dihydro-PGE1 prostaglandins GC/MS deuterium isotopes PGA2-d4 internal standards deuterated LC/MS GC-MS LC-MS mass spectrometry gas liquid chromatography spectroscopy

Product Overview:
13,14-dihydro Prostaglandin E1-d4 (13,14-dh PGE1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh PGE1 by GC- or LC-mass spectrometry. 13,14-dh PGE1 is an inhibitor of ADP-induced platelet aggregation in human platelet-rich plasma and washed platelets with IC50 values of 31 and 21 nM, respectively.{1607} 13,14-dh PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 of 40 nM.{960} Also, 13,14-dh PGE1 activates adenylate cyclase in NCB-20 hybrid cells with a Kact of 668 nM.{1926}

Size	25 µg
Shipping	dry ice
Molecular Formula	C₂₀H₃₂D₄O₅
SMILES	CCCCC[C@H](O)CC[C@H]([C@H]1CCCC([2H])([2H])C([2H])([2H])CC(O)=O)[C@H](O)CC1=O
Molecular Weight	360,5
Formulation	A solution in methyl acetate
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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