AMP+ MaxSpec® Kit

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AMP⁺ MaxSpec^® Kit

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Cat No: 710000

Assay Kits - Maxspec® Kits

Many lipids have a free carboxylic acid group that typically requires a weak acid mobile phase to ensure retention by HPLC. Unfortunately, the presence of the acid in the mobile phase also suppresses anion formation and often leads to poor electrospra...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

MS spec kits assays measures measurements N-(4-aminomethylphenyl)pyridinium AMPP salts quaternary ammonium reagents eicosanoids sensitivity sensitivities Michael H. Frantisek Turecek James Bollinger US 2011/0294153 USPT A1 13/078,652 carboxylic acids derivatives pyridiniums C12H13N2+ charged chemicals free amides compound-specific fragmentations MS/MS derivative-specific AMP-derivatized AMP+-derivatized

Product Overview:
Many lipids have a free carboxylic acid group that typically requires a weak acid mobile phase to ensure retention by HPLC. Unfortunately, the presence of the acid in the mobile phase also suppresses anion formation and often leads to poor electrospray ionization and poor MS sensitivity. Cayman’s AMP+ MaxSpec® Kit contains a positively charged reagent (AMP+) that can be coupled quantitatively to free carboxylic acids through an amide bond linkage. The resulting derivatized product thus contains a positively charged group that shows improved electrospray ionization and consequently improved MS sensitivity. Cayman’s derivatization reagent is stable to MS/MS fragmentation and thus isobaric derivatives undergo compound-specific fragmentation to give unique fragment ions. Limitations: This kit, when used per the instructions outlined in the booklet, produces derivatized stearic acid and palmitic acid interference peaks. Due to these interferences, this kit should not be used for the detection or identification of these two acids in samples.{60074,60075}

Size	15 tests
Shipping	dry ice
Custom Code	3822.19
UNSPSC code	12161503

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.