DUB Activity Assay Kit

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Cat No: 701490

Assay Kits - Enzyme Activity

Deubiquitinating enzymes (DUBs) remove ubiquitin from modified proteins in order to recycle ubiquitin attached to inappropriate targets, to remove and disassemble polyubiquitin chains, and to process proteins prior to their degradation by the proteaso...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

ubiquitination monoubiquitination polyubiquitination mono poly cell cycle differentiation immune responses DNA repair chromatin structure apoptosis in vitro 15981

Product Overview:
Deubiquitinating enzymes (DUBs) remove ubiquitin from modified proteins in order to recycle ubiquitin attached to inappropriate targets, to remove and disassemble polyubiquitin chains, and to process proteins prior to their degradation by the proteasome.{26595} They have been implicated in a number of human diseases and thus, are attractive targets for potential therapeutic intervention via the development of suitable inhibitors and modulators.{26597,26595} Cayman's DUB Activity Assay Kit facilitates the rapid, robust measurement of deubiquitinating enzyme activity in vitro. The kit utilizes a high purity, fluorogenic substrate (ubiquitin-AMC) together with suitable calibration standards and controls for the accurate and sensitive assessment of DUB activity. Continuous kinetic or end-point assays can be performed in a 96-well plate format for multi-sample analysis.

Size	96 wells
Shipping	dry ice
Custom Code	3822.19
UNSPSC code	41116104

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.