Aldehyde Dehydrogenase Activity

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Aldehyde Dehydrogenase Activity Assay Kit

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Cat No: 700800

Assay Kits - Enzyme Activity

Aldehyde dehydrogenases (ALDHs) represent a group of enzymes that oxidize a wide range of endogenous and exogenous aldehydes to their corresponding carboxylic acids, which affect both developmental and toxicological functions. Pharmacological inhibito...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

kits assays measures measurements ALDHs enzymes oxidizes oxidations endogenous exogenous aldehydes dehydrogenases carboxylic acids metabolisms amino carbohydrates lipids biogenic amines vitamins steroids humans superfamily isozymes physiological toxicological ALDH1A subfamily embryogenesis developments mediates mediating retinoic signaling signals signalling ALDH2 acetaldehydes cells tissues alcohol ingestions carcinogenesis ALDH1A1 ALDH3A1 lens corneal crystallins cellular defenses mechanisms UV ultraviolet radiations radiation-induced damages ocular cancers stems pharmacologicals inhibits inhibitors inhibitions anticancers anti anti-cancers oxazaphophorines drugs diseases Type II 2 hyperprolinemia Sjogrens Sjogren-Larsson Syndromes Parkinson's cardiac hearts hyperammonemia fluoroescence-based methods fluorescent homogenates cultures samples purified preparations fluorometrics

Product Overview:
Aldehyde dehydrogenases (ALDHs) represent a group of enzymes that oxidize a wide range of endogenous and exogenous aldehydes to their corresponding carboxylic acids, which affect both developmental and toxicological functions. Pharmacological inhibitors or activators of ALDH activity have been developed to examine the metabolism of alcohol as well as a number of pathological conditions, including cancer, Type II hyperprolinemia, Sjögren-Larsson Syndrome, Parkinson’s Disease, Cardiac Disease, and hyperammonemia. Cayman’s Aldehyde Dehydrogenase Assay provides a fluorescence-based method for detecting ALDH activity in tissue homogenates, cell culture samples, and purified ALDH preparations. In the assay, ALDH catalyzes the oxidation of acetaldehyde to acetic acid, along with the concomitant reduction of NAD+ to NADH. NADH reacts with the fluorometric developer to yield a highly fluorescent product which can be analyzed with an excitation wavelength of 530-540 nm and an emission wavelength of 585-595 nm.

Size	96 wells
Shipping	dry ice
Custom Code	3822.19
UNSPSC code	41116104

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.