€474.00 €402.90
Platelet-activating factor acetylhydrolase (PAF-AH) is a calcium-independent member of the phospholipase A2 (PLA2) family that hydrolyzes the acetyl group at the sn-2 position of PAF, a phospholipid mediator involved in a variety of biological activities.{64074,42494} There are three types of PAF-AH: two intracellular forms, PAF-AH1 and PAF-AH2, which are ubiquitously expressed, and an extracellular form, lipoprotein-associated phospholipase A2 (Lp-PLA2), which is found in the plasma in association with LDL and HDL.{42493,64077,64075}. Unlike PAF-AH1, which is largely restricted to hydrolysis of PAF, PAF-AH2 and Lp-PLA2 exhibit broader substrate specificity, hydrolyzing phospholipids with oxidized or short sn-2 acyl chains in addition to PAF.{42494,42493} PAF-AH1 has roles in neuronal development, protein trafficking, and spermatogenesis, and PAF-AH2 and Lp-PLA2 have a protective roles against oxidative stress and atherosclerosis, respectively.{64078} Cayman’s PAF-acetylhydrolase (human) Polyclonal Antibody can be used for Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Synthetic peptide corresponding to the C-terminal region of human PAF-AH |
| Application(s) | WB |
| Formulation | 500 µl of peptide affinity-purified antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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