CysLT2 Receptor (N-Term) Polyclo

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CysLT₂ Receptor (N-Term) Polyclonal Antibody

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Cat No: 120560

Cysteinyl leukotriene receptor 2 (CysLT2) is a G protein-coupled receptor that mediates the actions of leukotriene C4 (LTC4), LTD4, and, to a lesser extent, LTE4.{8519} It is expressed primarily in the heart, placenta, spleen, lymph nodes, and periphe...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

cysteinyl-leukotrienes receptors antibodies LTC4 LTD4 LTE4 Cys-LT2 human flow cytometry asthma peptido-leukotrienes western blots blotting antisera antiserum nt wb icc immuncytochemistry ihc atherosclerosis immunohistochemistry facs flow cytometry immunoblotting FC

Product Overview:
Cysteinyl leukotriene receptor 2 (CysLT2) is a G protein-coupled receptor that mediates the actions of leukotriene C4 (LTC4), LTD4, and, to a lesser extent, LTE4.{8519} It is expressed primarily in the heart, placenta, spleen, lymph nodes, and peripheral blood leukocytes.{8519,9059} Signaling induced by LTC4 through the CysLT2 receptor induces the production of chemokines via NF-κB and AP-1 activation in endothelial cells, indicating a role in inflammation.{61593} A CysLT2 receptor containing a leucine-to-glutamine substitution at position 129 (L129Q) has been found in human uveal melanoma cells and is associated with tumorigenesis in vivo.{61594,61595} SNPs in CYSLTR2 are associated with aspirin intolerance in patients with asthma.{61596} Cayman’s CysLT2 Receptor (N-Term) Polyclonal Antibody can be used for ELISA, flow cytometry (FC), and Western blot (WB) applications.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to the N-terminal region of human CysLT2
Application(s)	ELISA, FC, and WB
Formulation	Peptide affinity-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.