Monoacylglycerol Lipase Polyclon

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Monoacylglycerol Lipase Polyclonal Antibody

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Cat No: 100035

Endocannabinoids, such as arachidonoyl ethanolamide (AEA) and 2-Arachidonoyl glycerol (2-AG), function as short-range modulators of cell and synaptic activity. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to terminate its biological actions and wor...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

WB western blots hydrolases antibodies antiserum antisera hydrolysis immunohistochemistry IHC immunoblotting MGL monoacylglycerol neuroscience neurochemistry MAGL monoglycerol blotting

Product Overview:
Endocannabinoids, such as arachidonoyl ethanolamide (AEA) and 2-Arachidonoyl glycerol (2-AG), function as short-range modulators of cell and synaptic activity. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to terminate its biological actions and works consecutively with hormone-sensitive lipase (HSL) to mobilize fatty acids from the triglyceride stores of adipocytes.{11364,11436} MAGL has a molecular weight of ~33 kDa and exhibits a high degree of homology among human, mouse, and rat at the amino acid level.{11364,11436,5105,10671} The enzyme is expressed in a variety of tissues with most abundant expression in skeletal muscle and adipose tissue, suggesting a role of MAGL in monoglyceride hydrolysis in diverse tissues. Cayman Chemical’s MAGL polyclonal antibody can be used for western blot and immunohistochemical (formalin-fixed paraffin-embedded tissue) analysis for MAGL on samples of human, mouse, rat, and bovine origin. Other applications for use of this antibody have not yet been tested.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide from human MAGL
Application(s)	IHC (formalin-fixed paraffin-embedded tissue) and WB
Formulation	500 ?l of peptide affinity-purified IgG
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.