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TRIM

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    TRIM
  • TRIM
Cat No: 81310
Biochemicals - Small Molecule Inhibitors
Cayman

TRIM is an inhibitor of nNOS and iNOS. It exhibits IC50 values of 28.2 µM, 27.0 µM, and 1.06 mM for the inhibition of nNOS (mouse), iNOS (rat), and eNOS (bovine), respectively.{5918} TRIM inhibits mouse nNOS with Ki values of 47.3 and 462 µM in the ab...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 1-[2-(trifluoromethyl)phenyl]-1H-imidazole
Correlated keywords:
  • inhibitors nNOS iNOS arginine tetrahydobiopterin nitric oxide synthase
Product Overview:
TRIM is an inhibitor of nNOS and iNOS. It exhibits IC50 values of 28.2 µM, 27.0 µM, and 1.06 mM for the inhibition of nNOS (mouse), iNOS (rat), and eNOS (bovine), respectively.{5918} TRIM inhibits mouse nNOS with Ki values of 47.3 and 462 µM in the absence and presence of BH4, respectively, suggesting TRIM interferes with both arginine and tetrahydrobiopterin binding.{6635}
Size 50 mg
Shipping dry ice
CAS Number 25371-96-4
Molecular Formula C10H7N2F3
SMILES FC(F)(F)c1ccccc1n1cncc1
Molecular Weight 212,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.29
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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